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The Effect of Glibenclamide Administration on Insulin Sensitivity and Insulin Binding to Monocytes in Normal Subjects
Author(s) -
Olczak S. A.,
Greenwood R. H.,
Hales C. N.
Publication year - 1985
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1985.tb00649.x
Subject(s) - glibenclamide , medicine , proinsulin , insulin , endocrinology , bolus (digestion) , insulin sensitivity , diabetes mellitus , insulin resistance
Insulin sensitivity and insulin binding to monocytes were determined in seven normal subjects before and after one week's treatment with glibenclamide 2 mg three times daily. Glibenclamide administration produced a 60% increase in maximal specific insulin binding to monocytes. There was no effect on the blood glucose response to an intravenous bolus of insulin but fasting blood glucose was significantly elevated following glibenclamide treatment. Statistically significant changes in the fasting levels of plasma C‐peptide and serum proinsulin were not detected.