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The Effect of Mixing Human Soluble and Human Crystalline Zinc‐suspension Insulin: Plasma Insulin and Blood Glucose Profiles after Subcutaneous Injection
Author(s) -
Francis A. J.,
Hanning I.,
Alberti K. G. M. M.
Publication year - 1985
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1985.tb00629.x
Subject(s) - medicine , insulin , endocrinology , subcutaneous injection , human insulin , zinc , mixing (physics) , suspension (topology) , chemistry , mathematics , quantum mechanics , homotopy , pure mathematics , organic chemistry , physics
The effect of mixing human soluble insulin with two newly developed formulations of human crystalline zinc‐suspension insulin was studied in two groups of 8 normal and 6 diabetic subjects. Mixing Human Actrapid with Human Ultratard and Humulin‐S with Humulin‐Zn, for 60s before subcutaneous injection, significantly blunted the rise in free insulin levels ( p <0.05) and the onset of action of the short‐acting insulins ( p <0.01). The loss of solubility that occurs on mixing these insulins, with the consequent loss of the rapid acting component, may diminish their therapeutic usefulness in the control of post‐prandial blood glucose.