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Diabetic Ketoacidosis due to Insulin Resistance Treated by Haemodialysis
Author(s) -
Sheldon J.,
Hollis P. R.,
Trafford J. A. P.,
Cook J. G. H.
Publication year - 1985
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1985.tb00595.x
Subject(s) - medicine , insulin resistance , insulin , diabetic ketoacidosis , ketoacidosis , endocrinology , diabetes mellitus , type 1 diabetes
A 14‐year‐old female patient with insulin resistance is reported in whom it appeared that initially insulin breakdown was unusually rapid. Subsequently there was in addition evidence of reduced insulin sensitivity. The rapidly increasing requirement of insulin (1600 units daily), given by continuous IV infusion, was dramatically reduced by haemodialysis, and was maintained subsequently. We suggest that insulin aggregates which may have blocked insulin receptor sites, causing insulin resistance, were removed by haemodialysis.