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Urinary Insulin Excretion Rate: An Index of Free Insulinaemia in Insulin‐dependent Diabetics
Author(s) -
Pickup J. C.,
Collins A. C. G.,
Keen H.
Publication year - 1984
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1984.tb01975.x
Subject(s) - medicine , insulin , endocrinology , urinary system , excretion , immunoassay , diabetes mellitus , urine , antibody , immunology
In 25 insulin‐dependent diabetics, 14 managed by conventional insulin injection treatment (CIT) and 11 treated by continuous subcutaneous insulin infusion (CSII), there was a highly significant correlation between urinary insulin excretion rate (IER) per 1.73 m 2 and mean serum free insulin concentration ( r = 0.73, p <0.001), measured over a 24 h period. Urinary IER and mean daily serum free insulin levels were significantly higher in diabetics than in non‐diabetics. CSII‐treated patients had significantly lower mean 24 h plasma glucose levels than CIT‐treated patients despite similar values of urinary IER and mean daily serum free insulin in the two groups. Urinary IER may be a useful indicator of average insulinaemia in large scale studies, avoiding the problems of multiple blood sampling and immunoassay in the presence of anti‐insulin antibodies.