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Insulin Action and Pharmacokinetics in Insulin Treated Diabetics during the Third Trimester of Pregnancy
Author(s) -
Gray R. S.,
Cowan P.,
Steel J. M.,
Johnstone F. D.,
Clarke B. F.,
Duncan L. J. P.
Publication year - 1984
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1984.tb01972.x
Subject(s) - medicine , insulin , endocrinology , pharmacokinetics , pregnancy , insulin resistance , biology , genetics
Insulin action and pharmacokinetics were compared, using the euglycaemic insulin clamp technique, in seven insulin‐treated diabetics during the third trimester of pregnancy and one to three weeks post‐partum. At an insulin infusion rate of 1 mU/kg/min, insulin mediated glucose disposal was significantly greater ( p <0.02) following delivery (1.194±0.138 mmol/m 2 /min) than in pregnancy (0.761±0.072 mmol/m 2 /min) and the rate of decline in insulin mediated glucose disposal, at the end of the insulin infusion, was significantly greater ( p <0.02) following delivery (24.78±4.22 μmol/m 2 /min 2 ) than in pregnancy (15.17±2.00 μmol/m 2 /min 2 ). The metabolic clearance rate, distribution space and pharmacological half‐life of insulin were not significantly altered by pregnancy. These findings show that the third trimester of pregnancy is associated with steady state insulin resistance accompanied by a reduced rate of insulin deactivation, but normal insulin pharmacokinetics.