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Need Stable Diabetics Mix their Insulins?
Author(s) -
Roland J. M.
Publication year - 1984
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1111/j.1464-5491.1984.tb01923.x
Subject(s) - medicine , crossover study , insulin , diabetes mellitus , gastroenterology , endocrinology , alternative medicine , pathology , placebo
Ten insulin‐dependent diabetics taking twice‐daily mixtures of soluble and isophane insulin were studied in a double‐blind crossover trial to examine the effect on their glycaemic control of a fixed‐mixture preparation (containing either 50% soluble, 50% isophane or 30% soluble, 70% isophane) given in the same total dose as each patient's usual mixture. The mean (± S.E.M.) of eight daily blood glucose determinations when the patients' usual mixtures were pre‐mixed by the hospital pharmacy was 7.6±0.7 mmol/I, 7.8±0.8 mmol/I when the fixed‐mixture preparation was used and 8.0± 0.5 mmol/I when the patients drew up and mixed the insulins themselves. Individual glucose profiles on each of the three regimens expressed as mean modified log ‘M’ indices were 1.2 ± 0.14, 1.29 ± 0.16 and 1.37 ± 0.14, respectively. Thus, the patients studied were as well controlled on a fixed‐mixture preparation as on their usual ‘tailormade’ insulin regimens.