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In situ and intraductal epithelial proliferations of prostate: definitions and treatment implications
Author(s) -
Clouston David,
Bolton Damien
Publication year - 2012
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/j.1464-410x.2012.11612.x
Subject(s) - high grade prostatic intraepithelial neoplasia , intraepithelial neoplasia , prostate , medicine , adenocarcinoma , carcinoma in situ , pathology , biopsy , prostate cancer , oncology , urology , carcinoma , cancer
High‐grade prostatic intraepithelial neoplasia (HGPIN) is an intracellular proliferation of ductal epithelial cells. On its own, the presence of HGPIN does not warrant active intervention. In contrast, intraductal carcinoma of prostate and prostatic ductal adenocarcinoma of prostate are markers of aggressive prostatic adenocarcinoma. The presence of even small foci of these tumours on biopsy warrants immediate intervention, even in the absence of demonstrable invasive disease. This second part of the review of in situ epithelial proliferations of the prostate looks at these conditions in more detail.