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Diagnostic tests in urology: percentage of free prostate‐specific antigen ( PSA )
Author(s) -
Yi Yooni,
Breau Rodney H.,
Witiuk Kelsey,
Neuberger Molly M.,
Dahm Philipp
Publication year - 2013
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/j.1464-410x.2012.11446.x
Subject(s) - prostate specific antigen , prostate cancer , urology , medicine , strengths and weaknesses , prostate , prostate cancer screening , cancer , oncology , psychology , social psychology
What's known on the subject? and What does the study add? Free to total PSA ratios are commonly used as an adjunct to total PSA levels to better define an individual's risk for prostate cancer; however, its strengths and weaknesses are not well understood. This article illustrates the use of likelihood ratios that can be generated from the reported sensitivities and specificities from given free to total PSA thresholds in either increasing or decreasing an individual patient's probability of prostate cancer. Understanding the strengths and limitations of free to total PSA testing will help clinicians anticipate whether its use is indicated or not.