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Prognostic factors for recent‐onset interstitial cystitis/painful bladder syndrome
Author(s) -
Warren John W.,
Clauw Daniel J.,
Langenberg Patricia
Publication year - 2013
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/j.1464-410x.2012.11422.x
Subject(s) - interstitial cystitis , nocturia , medicine , prospective cohort study , urinary urgency , bladder pain syndrome , natural history , logistic regression , urinary system , pelvic pain , surgery , overactive bladder , pathology , alternative medicine
Study Type – Prognosis (case series) Level of Evidence 4 What's known on the subject? and What does the study add? Interstitial cystitis/painful bladder syndrome (IC/PBS) comprises pain perceived to be from the bladder, urinary urgency and frequency, and nocturia. As diagnosed at present, it is primarily identified in adult women. It is a chronic disease yet its natural history has not been well studied. In a prospective study of 304 incident female IC/PBS cases followed for a median of 33 months after onset, women with baseline chronic fatigue syndrome had a worse prognosis for IC/PBS. Mild IC/PBS at baseline was the only variable that was directly associated with a good prognosis. OBJECTIVE• To identify baseline variables that predict the prognosis of interstitial cystitis/painful bladder syndrome (IC/PBS) in women seeking medical care for recent onset of this syndrome.SUBJECTS AND METHODS• In a prospective study of women with incident IC/PBS (≤12 months of symptoms), we contacted patients at intervals and asked standardized questions about IC/PBS symptoms in the previous week. • Logistic regression analyses assessed baseline variables as predictors of mild vs more severe IC/PBS at the last follow‐up.RESULTS• Median length of follow‐up was 33 months after onset of IC/PBS; 304 (97%) patients had at least one follow‐up assessment. • Mild IC/PBS at baseline was the only variable that was directly associated with a mild IC/PBS endpoint. • Conversely, a history of chronic fatigue syndrome (CFS) was inversely associated with a mild endpoint of IC/PBS (i.e. individuals with CFS had a worse prognosis for their IC/PBS symptoms).CONCLUSIONS• At a median of nearly 3 years after onset, baseline mild IC/PBS was directly associated with a milder disease severity. • Baseline co‐morbid CFS was associated with more severe disease. • Whether CFS was uniquely associated or represented several co‐morbid non‐bladder syndromes (NBSs) could not be determined.