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Rational indication for docetaxel rechallenge in metastatic castration‐resistant prostate cancer
Author(s) -
Heck Matthias M.,
Thalgott Mark,
Retz Margitta,
Wolf Petra,
Maurer Tobias,
Nawroth Roman,
Hatzichristodoulou Georgios,
Gschwend Jürgen E.,
Kübler Hubert
Publication year - 2012
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/j.1464-410x.2012.11364.x
Subject(s) - docetaxel , medicine , prostate cancer , chemotherapy , oncology , prednisone , prostate specific antigen , cancer
Study Type – Therapy (case series) Level of Evidence 4 What's known on the subject? and What does the study add? Docetaxel rechallenge has shown preserved anti‐tumour activity and has therefore been proposed as an option for further treatment in patients with metastatic castration‐resistant prostate cancer, who have shown a good response to first‐line chemotherapy with docetaxel. The present study provides evidence of docetaxel activity in patients who were treated with full‐dose (75 mg/m 2 ) 3‐weekly docetaxel at first‐line chemotherapy and rechallenge. It shows that PSA response to first‐line chemotherapy may provide a rational indication for docetaxel rechallenge. OBJECTIVE• To determine whether prostate‐specific antigen (PSA) response at first‐line chemotherapy with docetaxel correlates with PSA response and survival at docetaxel rechallenge in patients with metastatic castration‐resistant prostate cancer (mCRPC).PATIENTS AND METHODS• We retrospectively evaluated the oncological outcomes of patients with mCRPC, who were treated with full‐dose (75 mg/m 2 ), 3‐weekly docetaxel plus prednisone/prednisolone at first‐line chemotherapy and rechallenge, between 1999 and 2011, at our institution. • The endpoints were PSA‐progression‐free survival (PSA‐PFS) and overall survival (OS) at docetaxel rechallenge. • Statistical analyses included Kaplan–Meier curves and log‐rank tests to evaluate the effect of PSA response at first‐line chemotherapy on PSA‐PFS and OS at rechallenge.RESULTS• Fourty‐four patients were included in the analysis. • At a median (range) follow‐up of 26.4 (9.8–89.8) months after the first administration of docetaxel, 24 (55%) patients had died. At first‐line chemotherapy, 36 (82%) patients achieved a reduction in PSA level of ≥50%. At rechallenge, 10 (28%) patients responded with a reduction of ≥50% for a second time. • The median (95% confidence interval [CI]) PSA‐PFS was 5.9 (95% CI 3.5–6.8) months and the median OS was 21.8 (95% CI 19.9–23.7) months at docetaxel rechallenge. • Of the PSA response variables evaluated, only a PSA level reduction of ≥50% at first‐line chemotherapy correlated significantly with prolonged PSA‐PFS (5.8 vs. 4.5 months; P = 0.01) and OS (22.1 vs. 7.2 months; P = 0.03) at rechallenge.CONCLUSION• In the present single‐institution study, a reduction in PSA level of ≥50% at first‐line chemotherapy with docetaxel correlated with superior PSA‐PFS and OS in the rechallenge setting and might, therefore, present a rational indication for docetaxel rechallenge.