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A review of expression profiling of circulating microRNAs in men with prostate cancer
Author(s) -
Kelly Brian D.,
Miller Nicola,
Healy Nuala A.,
Walsh Kilian,
Kerin Michael J.
Publication year - 2013
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/j.1464-410x.2012.11244.x
Subject(s) - microrna , prostate cancer , biomarker , cancer , prostate , medicine , gene expression profiling , computational biology , bioinformatics , non coding rna , gene expression , biology , cancer research , gene , genetics
What's known on the subject? and What does the study add? MicroRNAs are small, single‐stranded RNA molecules that are stable in the circulation. These molecules have been identified as potential circulating biomarkers for several malignancies. In this review we provide a comprehensive overview of the publications that have identified dysregulated microRNAs in the circulation of men with prostate cancer.MicroRNAs ( miRNAs ) are small non‐coding RNAs that are involved in gene regulation and expression. These molecules have been implicated in the pathogenesis of several malignancies. MiRNAs have the potential to be both a tissue‐ and blood‐based biomarker for cancer diagnosis, classification, prognosis and response to treatment. The levels of dysregulated miRNAs in the circulation of individuals make miRNAs an ideal biomarker for the detection of prostate cancer. The present study provides a comprehensive review of the expression profiling of miRNAs in the circulation of men with prostate cancer. Further research is necessary to identify if circulating miRNAs have the potential to be a biomarker for prostate cancer in clinical practice.