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Correlation between expression of α 1 ‐adrenoceptor subtype mRNA and severity of lower urinary tract symptoms or bladder outlet obstruction in benign prostatic hyperplasia patients
Author(s) -
Kojima Yoshiyuki,
Sasaki Shoichi,
Imura Makoto,
Kubota Yasue,
Hayashi Yutaro,
Kohri Kenjiro
Publication year - 2011
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/j.1464-410x.2010.09596.x
Subject(s) - medicine , lower urinary tract symptoms , prostate , hyperplasia , urology , bladder outlet obstruction , international prostate symptom score , stepwise regression , correlation , prostate biopsy , prostate cancer , biopsy , cancer , geometry , mathematics
Study Type – Aetiology (case control)
Level of Evidence 3b What’s known on the subject? and What does the study add? Although there are several reports about distribution and localization of α 1 ‐adrenoceptor (AR) subtypes in the prostate, there has been no report to demonstrate the correlation with the clinical findings of benign prostatic hyperplasia (BPH) patients. OBJECTIVE• To examine whether the direct correlation between the expression of α 1 ‐adrenoceptor (AR) subtype mRNA and severity of lower urinary tract symptoms (LUTS) or bladder outlet obstruction (BOO) in the prostate exists in benign prostatic hyperplasia (BPH) patients.PATIENTS AND METHODS• Sixty‐eight patients with LUTS and BOO secondary to BPH were enrolled. Four prostate needle biopsy specimens were obtained from the transition zone to examine the expression level of α 1 ‐AR subtypes by Taqman reverse‐transcription polymerase chain reaction. • The correlation and regression between each expression level of α 1 ‐AR subtype and clinical findings such as patient age, prostate volume, International Prostate Symptom Score (IPSS), quality of life (QOL) index, maximum flow rate in uroflowmetry (Qmax) and post‐void residual urine volume (PVR) were assessed by stepwise multiple regression analysis. • The correlation and regression between this expression level and individual symptoms of IPSS were assessed by Pearson’s correlation coefficient and multiple regression analyses.RESULTS• Stepwise multiple regression analysis showed that the expression levels of α 1a ‐AR, α 1b ‐AR, α 1d ‐AR and total α 1 ‐AR mRNA showed a significant regression with patient age, but not with prostate volume, IPSS, QOL index, Qmax and PVR. • Pearson’s correlation coefficient and multiple regression analyses demonstrated no correlation and regression between each α 1 ‐AR subtype mRNA expression level and individual symptoms of IPSS.CONCLUSIONS• There was no direct correlation between the expression of α 1 ‐AR subtype mRNA in the prostate and severity of LUTS or BOO in BPH patients, although the significant regression of this expression with patient age existed. • LUTS and BOO may be associated with multiple factors and several other conditions may contribute to LUTS and BOO.