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Bladder cancer in cystoscopically normal‐appearing mucosa: a case of mistaken identity?
Author(s) -
Herr Harry W.,
AlAhmadie Hikmat,
Dalbagni Guido,
Reuter Victor E.
Publication year - 2010
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/j.1464-410x.2010.09332.x
Subject(s) - urothelium , medicine , cystoscopy , malignancy , carcinoma in situ , biopsy , bladder cancer , pathology , carcinoma , stage (stratigraphy) , cancer , urinary bladder , urology , alternative medicine , paleontology , biology
Study Type – Diagnosis (exploratory cohort)
Level of Evidence 2b OBJECTIVE To test the frequency of malignancy in normal‐appearing urothelium in patients with high‐risk bladder cancer, as biopsy of normal‐appearing mucosa using standard white‐light cystoscopy (WLC) reportedly shows carcinoma in situ (CIS) in some patients with bladder tumours. PATIENTS AND METHODS Cold‐cup biopsies of normal‐appearing mucosa were obtained by two experienced oncological urologists from 63 patients during transurethral resection of bladder cancers. Each biopsy labelled as ‘normal’ was interpreted by two expert uropathologists. RESULTS Each of the biopsies in all 63 patients was interpreted by both urological pathologists as showing normal or benign histology, except that one showed focal CIS. CONCLUSIONS Bladder urothelium appearing normal to expert urological oncologists using standard WLC rarely shows CIS when biopsies are evaluated by experienced uropathologists.