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Application of mesenchymal stromal cells in urological diseases
Author(s) -
Montzka Katrin,
Heidenreich Axel
Publication year - 2010
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/j.1464-410x.2009.09077.x
Subject(s) - mesenchymal stem cell , stromal cell , clinical uses of mesenchymal stem cells , stem cell , adipose tissue , stem cell transplantation for articular cartilage repair , tissue engineering , bone marrow , adult stem cell , embryonic stem cell , biology , medicine , immunology , cancer research , microbiology and biotechnology , biomedical engineering , biochemistry , gene
The application of stem cells and their use in tissue‐engineering approaches is emerging in clinical therapeutic intervention strategies. The use of adult stem cells, either autologous or allogenic, does not raise ethical concerns, in contrast to embryonic stem cells. Mesenchymal stromal cells (MSCs) can be easily obtained from bone marrow or from adipose tissue and further expanded in vitro . Due to their differentiation capacity, MSCs are very attractive for tissue engineering purposes. Furthermore, MSCs secrete a variety of mediators that have beneficial effects on the regenerating tissue. In this review we give an insight into stem cell hierarchy, define the properties of MSCs and summarize recent reports of their administration in urological diseases.