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Chronic kidney disease among men with lower urinary tract symptoms due to benign prostatic hyperplasia
Author(s) -
Hong Sung Kyu,
Lee Seung Tae,
Jeong Sung Jin,
Byun SeokSoo,
Hong Young Kwon,
Park Dong Soo,
Hong Jae Yup,
Son Jeong Hwan,
Kim Cheil,
Jang Seok Heun,
Lee Sang Eun
Publication year - 2010
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/j.1464-410x.2009.08975.x
Subject(s) - medicine , lower urinary tract symptoms , international prostate symptom score , urology , kidney disease , renal function , diabetes mellitus , hyperplasia , body mass index , comorbidity , creatinine , univariate analysis , multivariate analysis , prostate , gastroenterology , endocrinology , cancer
Study Type – Diagnosis (case series)
Level of Evidence 4 OBJECTIVE To analyse potential association of various clinical characteristics of benign prostatic hyperplasia (BPH) with chronic kidney disease (CKD) among men presenting with lower urinary tract symptoms (LUTS) secondary to BPH of varying severity. PATIENTS AND METHODS We reviewed the data of 2741 consecutive patients who presented to our clinic with LUTS secondary to BPH. For our analysis, CKD was defined by an elevated serum creatinine level or decreased estimated glomerular filtration rate (eGFR). Univariate and multivariate logistic regression analyses were used to address associations of CKD with various clinical characteristics. RESULTS Of the 2741 patients, 161 (5.9%) were initially classified as having CKD (serum creatinine ≥133 µmol/L). In multivariate analysis, peak flow rate ( P = 0.001) and a history of hypertension and/or diabetes (both P < 0.001) were significantly associated with CKD, whereas age, body mass index, prostate‐specific antigen level, prostate volume, postvoid residual, or International Prostate Symptom Score (IPSS) were not. When individual symptoms from the IPSS were analysed, only weak stream ( P = 0.041) and hesitancy ( P = 0.048), both obstruction‐related, were significantly associated with CKD status in age and comorbidity‐adjusted analyses. The results of secondary analysis with CKD defined as an eGFR of <60 mL/min/1.73 m 2 were similar. CONCLUSION Our results show that decreased peak flow rate and a history of hypertension and/or diabetes are significantly associated with CKD in men seeking management for LUTS from BPH of varying severity.