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The relevance of a hypoxic tumour microenvironment in prostate cancer
Author(s) -
Stewart Grant D.,
Ross James A.,
McLaren Duncan B.,
Parker Christopher C.,
Habib Fouad K.,
Riddick Antony C.P.
Publication year - 2010
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/j.1464-410x.2009.08921.x
Subject(s) - prostate cancer , hypoxia (environmental) , medicine , prostate , tumor microenvironment , oncology , clinical significance , cancer , cancer research , chemistry , oxygen , organic chemistry
Research into the hypoxic tumour microenvironment is accelerating and the reversal of hypoxia is increasingly being suggested as a mechanism for improving cancer treatment. Recent studies have suggested that hypoxia is also a feature in prostate cancer and is associated with a poor prognosis. Hypoxia has been shown to cause radio‐resistance and hence hamper one of the major treatments for prostate cancer. However, unlike other solid tumours, such as cervical and head‐and‐neck cancer, there are inconsistencies and unanswered questions about the relevance of hypoxia in prostate cancer. This review outlines the role of low‐oxygen conditions in prostate cancer and the areas where further studies are required.