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Site of positive surgical margins influences biochemical recurrence after radical prostatectomy
Author(s) -
Godoy Guilherme,
Tareen Basir U.,
Lepor Herbert
Publication year - 2009
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/j.1464-410x.2009.08688.x
Subject(s) - prostatectomy , biochemical recurrence , urology , medicine , general surgery , prostate cancer , cancer
OBJECTIVE To determine whether the number and location of positive surgical margins (PSMs) in radical prostatectomy (RP) surgical specimens affect biochemical recurrence (BCR) rates. PATIENTS AND METHODS The locations of PSMs were recorded for 1308 consecutive men who underwent RP between October 2000 and December 2006. BCR was defined as three consecutive prostate‐specific antigen (PSA) level rises with the peak level ≥0.15 ng/mL. Multivariate regression analyses were used to identify preoperative predictors of PSMs and BCR. The estimated 5‐year risk of BCR was calculated using the Kaplan–Meier method. RESULTS In all, 128 (9.8%) men had one or more PSMs. The mean body mass index, mean preoperative serum PSA level, the distributions of clinical stage and biopsy Gleason scores, and the presence or absence of biopsy perineural invasion were significantly different between men with or with no PSMs. In multivariate analysis, baseline serum PSA level, Gleason score and perineural invasion were independent preoperative predictors of PSMs. The 5‐year actuarial BCR rates were dependent on the site of the PSM ( P = 0.035) and not the number of PSMs ( P = 0.18). The rank order of estimated 5‐year BCR rates according to the site of PSMs were base > anterior > posterolateral > apex ≈ posterior. CONCLUSIONS About half of the men with PSMs in the RP surgical specimen in our prospective series did not develop BCR. The risk of BCR was dependent on the site and not the number of PSMs. Adjuvant therapy should be considered in cases with anterior and basilar PSMs due to the very high risk of BCR.