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Listening to the patient: a flexible approach to the use of antimuscarinic agents in overactive bladder syndrome
Author(s) -
Chapple Christopher R.,
Rosenberg Matt T.,
Brenes Francisco J.
Publication year - 2009
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/j.1464-410x.2009.08545.x
Subject(s) - solifenacin , oxybutynin , overactive bladder , medicine , tolterodine , urology , urinary incontinence , dosing , alternative medicine , pathology
Several studies with modern antimuscarinics have used a flexible‐dosing strategy. We reviewed data from several studies with solifenacin, darifenacin and oxybutynin extended‐release that evaluated the impact of dose flexibility on clinical management. A strategy based on patient‐requested dose increases was found to be consistently effective in improving the symptoms of overactive bladder. Patients requesting a dose increase often had more severe symptoms at baseline than those who did not request a dose increase, and these patients derived most benefit from the increased dose. Specialists and family doctors should encourage open discussion with their patients about requesting dose titration so as to meet patients' individual needs.