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Sentinel lymph‐node biopsy in patients with squamous cell carcinoma of the penis
Author(s) -
Jensen Jørgen Bjerggaard,
Jensen Klaus MøllerErnst,
Ulhøi Benedicte Parm,
Nielsen Søren Steen,
Lundbeck Finn
Publication year - 2009
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/j.1464-410x.2009.08449.x
Subject(s) - medicine , sentinel lymph node , penis , penile cancer , biopsy , radiology , lymph node , dissection (medical) , surgery , lymph , carcinoma , cancer , pathology , breast cancer
OBJECTIVES To evaluate a single‐centre experience with sentinel lymph‐node biopsy (SLNB) as a staging procedure in patients with squamous cell carcinoma (SCC) of the penis. PATIENTS AND METHODS The study included 60 patients with SCC of the penis, who had SLNB in all groins where no palpable nodes were found, and in groins with palpable nodes with negative fine‐needle aspiration cytology. Lymphoscintigraphy and intraoperative lymph node detection was done using 99m Tc‐nanocolloid and no use of blue dye. RESULTS In all, there were 97 SLNB procedures in 52 patients; 20 (20.6%) of the SLNB were positive for nodal metastases. Two negative SLNB proved to be false‐negative during the observation period. The false negative‐rate was 9%, the sensitivity 91% and the negative predictive value 97.5%. Minor early complications occurred after 4% of the SLNB procedures. No major or late complications were recorded. CONCLUSIONS SLNB is minimally invasive and can be used as a safe and reliable staging procedure in patients with SCC of the penis. Thus standard lymph‐node dissection can be avoided in most patients.