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A multicolour fluorescence in situ hybridization test predicts recurrence in patients with high‐risk superficial bladder tumours undergoing intravesical therapy
Author(s) -
Whitson Jared,
Berry Anna,
Carroll Peter,
Konety Badrinath
Publication year - 2009
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/j.1464-410x.2009.08375.x
Subject(s) - medicine , bladder cancer , cystoscopy , hazard ratio , urology , univariate analysis , carcinoma in situ , proportional hazards model , cytology , predictive testing , fluorescence in situ hybridization , multivariate analysis , oncology , gastroenterology , pathology , cancer , disease , urinary system , confidence interval , biochemistry , chemistry , chromosome , gene
OBJECTIVE To determine whether a multicolour fluorescence in situ hybridization test (UroVysion TM , Abbott Molecular Inc., Des Plaines, IL, USA) in patients with high‐risk superficial bladder tumours maintains its predictive ability in a multivariate model for recurrence and progression, incorporating clinical and pathological predictors of outcome. PATIENTS AND METHODS The charts of patients with superficial bladder cancer treated with induction or maintenance intravesical therapy (IVT) were reviewed retrospectively. UroVysion testing was used at the beginning and end of each IVT cycle, and cytology and cystoscopy 6 weeks after completing each cycle. Kaplan‐Meier actuarial survival was analysed, stratified by the UroVysion result after IVT. Univariate and multivariate Cox regression analyses were used to identify significant predictors of recurrence. RESULTS In all, 42 patients had induction IVT with bacille Calmette‐Guérin (BCG), BCG + interferon, or mitomycin. The median follow‐up was 21 months. Recurrent disease was detected in 18 patients. In a univariate analysis, chronic renal insufficiency (hazard ratio 12.1, P = 0.03), positive cytology after IVT (2.7, P = 0.05), and a positive UroVysion test after IVT (8.3, P < 0.01) were predictive of failure. In the multivariate analysis, high grade disease (5.3, P = 0.05), a risk score of >6 (4.7, P = 0.02) and a positive UroVysion test after IVT (6.7, P < 0.01) were significant predictors of recurrence. CONCLUSION In patients with high‐risk superficial bladder tumours undergoing IVT, a positive UroVysion test after treatment is highly predictive of recurrence, even in a multivariate model. Additional adjuvant therapy might be necessary in these patients to improve the outcome.