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Is there a relationship between prostate volume and Gleason score?
Author(s) -
Mir Maria Carmen,
Planas Jacques,
Raventos Carles Xavier,
De Torres Ines Maria,
Trilla Enrique,
Cecchini Lluis,
Orsola Anna,
Morote Juan
Publication year - 2008
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/j.1464-410x.2008.07696.x
Subject(s) - medicine , biopsy , prostate , rectal examination , transrectal ultrasonography , prostate biopsy , prostatectomy , urology , prostate cancer , prostate specific antigen , radiology , cancer
OBJECTIVES To review the relationship between the Gleason grade and prostate volume in biopsy and radical prostatectomy (RP) specimens, and thus assess the hypothesis that smaller prostates have a greater incidence of high‐grade tumours. PATIENTS AND METHODS We selected 390 patients who had RP at our institution, with a prostate‐specific antigen (PSA) level of <10 ng/mL and who had not had hormonal therapy. We retrospectively reviewed the data for transrectal ultrasonography (TRUS)‐guided prostate biopsies from these patients and the RP specimens. Indications for biopsy included a PSA level of ≥4 ng/mL or an abnormal digital rectal examination. High‐grade tumours were defined as having a Gleason score of ≥7. RESULTS The TRUS volume was statistically related to the rate of high‐grade tumours at biopsy and RP. On multivariate analyses, TRUS volume was a significant predictor of high‐grade tumour for biopsy and RP specimens, with an inverse relationship between high‐grade tumours and prostate volume for biopsy and RP specimens. CONCLUSIONS Our data suggest that there is a relationship between the rate of high‐grade tumours and prostate volume even in biopsy and RP specimens and it is not an artefact related to the biopsy.