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The role of lymph‐node dissection in the treatment of upper urinary tract cancer: a multi‐institutional study
Author(s) -
Abe Takashige,
Shinohara Nobuo,
Harabayashi Toru,
Sazawa Ataru,
Ishikawa Shuhei,
Kubota Kanako,
Matsuno Yoshihiro,
Osawa Takahiro,
Shibata Takeshi,
Shinno Yuichiro,
Kamota Shinji,
Minami Keita,
Sakashita Shigeo,
Takeuchi Ichiro,
Kumagai Akira,
Mori Tatsuya,
Togashi Masaki,
omura Katsuya
Publication year - 2008
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/j.1464-410x.2008.07673.x
Subject(s) - medicine , lymph node , dissection (medical) , multivariate analysis , urology , upper urinary tract , lymphadenectomy , cancer , stage (stratigraphy) , urinary system , significant difference , surgery , paleontology , biology
OBJECTIVES To determine the role of lymph‐node (LN) dissection in patients undergoing surgery for upper urinary tract (UUT) cancer. PATIENTS AND METHODS We reviewed the clinicopathological data from 312 patients with UUT cancer treated predominantly by nephroureterectomy. The relationship between clinical characteristics and cancer‐specific survival (CSS) was analysed, focusing on node‐related information. RESULTS In all, 166 patients had LN dissection while 146 did not (pNx). Multivariate analysis showed that T stage, grade and pN status were significant variables for CSS. The difference in survival between the pN0 and pNx groups remained significant in a multivariate analysis. The median (range) number of LNs removed was 6 (1–65). There was no significant difference in CSS between the 72 patients with fewer than six LNs removed and the 78 with six or more removed. CONCLUSIONS LN dissection is important for postoperative stratification of patients with UUT cancer because node‐positive disease was one of the variables with a significant adverse effect on survival. In addition, the significant difference in survival between the pN0 and pNx groups might indicate a therapeutic benefit of LN dissection, although removing more LNs did not uniformly increase the probability of CSS.