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Inhibitory effect of sildenafil on the human isolated seminal vesicle
Author(s) -
Gajar Sessin A.,
Tano Tania,
Resende Ângela C.,
Bitencourt José Augusto F.,
De Lemos Neto Miguel,
Damião Ronaldo,
Criddle David N.,
Soares de Moura Roberto
Publication year - 2007
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/j.1464-410x.2007.07260.x
Subject(s) - sildenafil , inhibitory postsynaptic potential , seminal vesicle , pharmacology , chemistry , medicine , biology , endocrinology , prostate , cancer
OBJECTIVE To investigate the effects of sildenafil on noradrenaline‐ and potassium‐induced contractions of isolated human seminal vesicles (SVs), as premature ejaculation is a relatively common male sexual dysfunction that currently lacks an adequate therapy, and recent in vitro tests showed that sildenafil induces relaxation of rodent isolated SVs, but it is not known whether it also inhibits isolated human SV. MATERIAL AND METHODS Isolated strips of human SVs were suspended in an organ bath and cumulative concentration‐response curves to either noradrenaline or KCl were constructed in the presence and absence of sildenafil to evaluate its inhibitory actions. RESULTS Sildenafil (25–100 µ m ) induced concentration‐dependent inhibitory effects on the human SV contracted by either noradrenaline or KCl. These actions of sildenafil do not therefore appear to be mediated via a competitive antagonism of α‐adrenoceptors and are consistent with its recognized ability to inhibit phosphodiesterase‐5. CONCLUSIONS The present results show an important inhibitory action of sildenafil in the isolated human SV, supporting the therapeutic indication of this drug for treating premature ejaculation.