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Genetic impact on prostate anatomical variability during ageing: role of CYP17, SRD5A2 and androgen receptor genes polymorphisms
Author(s) -
Larré Stéphane,
Hamadeh Hikmat,
Azzouzi Abdel Rahmene,
Vallancien Guy,
CochandPriollet Beatrix,
CancelTassin Géraldine,
Cussenot Olivier
Publication year - 2007
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/j.1464-410x.2007.07079.x
Subject(s) - androgen receptor , prostate , stromal cell , androgen , allele , genotype , prostate cancer , medicine , biology , endocrinology , ageing , gene , genetics , cancer , hormone
OBJECTIVES To investigate the role of genetic determinism on individual variability in age‐related prostate changes, as defining ‘normal’ anatomy in prostate gland ageing is a challenge because the variability of changes in prostate morphology increases with age. MATERIALS AND METHODS We assessed the influence of androgen‐ and oestrogen‐regulating genetic polymorphisms on age‐related weight and stromal‐ratio changes in the prostate, using an anatomical, autopsy‐based study. We quantified weight and glandular/stromal ratio in 85 autopsy prostates from men aged > 50 years. We genotyped allelic variants of androgen‐regulating genes [androgen receptor (CAG repeats) and type II 5‐α reductase (TA repeat and V89L)] and an oestrogen‐regulating gene (A1/A2 variants of the 17α‐hydroxylase (CYP17)). RESULTS There was a fair negative correlation between prostate weight and the number of CAG repeats ( r = −0.32, P = 0.003); the group with ≤ 19 CAG repeats had heavier prostates than the ≥ 20 group ( P = 0.015). The stromal ratio was higher in the group with 20–23 CAG repeats ( P = 0.02) and in the A2A2 group of the CYP17 polymorphism ( P = 0.016) compared with the other groups mixed together. CONCLUSION A low number of CAG repeats is associated with higher prostate weights. The A2A2 genotype of CYP17 is associated with a higher stromal ratio.