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Long‐term follow‐up of living kidney donors: a longitudinal study
Author(s) -
ElAgroudy Amgad E.,
Sabry Alaa A.,
Wafa Ehab W.,
Neamatalla Ahmed H.,
Ismail Amani M.,
Mohsen Tarek,
Khalil Abd Allah,
Shokeir Ahmed A.,
Ghoneim Mohamed A.
Publication year - 2007
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/j.1464-410x.2007.07054.x
Subject(s) - medicine , nephrectomy , renal function , kidney transplantation , donation , creatinine , kidney , population , diabetes mellitus , overweight , transplantation , urology , surgery , body mass index , endocrinology , environmental health , economics , economic growth
OBJECTIVE To analyse retrospectively the general health status and renal and cardiovascular consequences of living‐related kidney donation, as the long‐term effects of unilateral nephrectomy for kidney donation are of particular interest with the currently increasing practice of living‐donor transplantation. PATIENTS AND METHODS Living‐related kidney donors (1400) who had donated their kidneys between 1976 and 2002 were asked to attend a dedicated donor follow‐up clinic starting in 2004. We attempted to contact all donors to determine the long‐term outcome of their remaining kidney. All kidney donors who responded had a detailed assessment, and were questioned about rehabilitation and their feelings on donating a kidney. The data were compared to the age‐matched health tables of the Egyptian general population. RESULTS In all, 339 donors had a complete evaluation (mean age at the time of evaluation 47.8 years, sd 11; mean follow‐up 10.7 years, sd 4.9). The mean ( sd ) creatinine level after donation was 1.1 (1.2) mg/dL, and creatinine clearance 109 (33) mL/min; the clearance was <60 mL/min in 0.9% of donors and proteinuria was >300 mg/24 h in 1.5% of donors. Seventy‐five (22.1%) donors became hypertensive and the rate was higher in donors with an interval of >25 years from donation; 174 (51.3%) of patients became either overweight or obese. Diabetes mellitus developed in 23 (6.8%) and was more common in patients with significant weight gain. CONCLUSIONS Donor nephrectomy has minimal adverse effects on overall health status. Regular donor follow‐up identifies at‐risk populations and potentially modifiable factors.