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Prospective non‐randomized evaluation of four mediators of the systemic response after extraperitoneal laparoscopic and open retropubic radical prostatectomy
Author(s) -
Jurczok Andreas,
Zacharias Mario,
Wagner Sigrid,
Hamza Amir,
Fornara Paolo
Publication year - 2007
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/j.1464-410x.2007.06849.x
Subject(s) - medicine , surgery , prospective cohort study , radical retropubic prostatectomy , pathological , urology , prostatectomy , randomized controlled trial , laparoscopic surgery , laparoscopy , prostate , cancer
Associate Editor Ash Tewari Editorial Board Ralph Clayman, USA Inderbir Gill, USA Roger Kirby, UK Mani Menon, USA OBJECTIVE To report a prospective, controlled, non‐randomized patient study to determine the systemic response to extraperitoneal laparoscopic (eLRP) and open retropubic radical prostatectomy (RRP). PATIENTS AND METHODS In all, 403 patients who had eLRP (163) or open RRP (240) were recruited; patients in both groups had similar preoperative staging. In addition to peri‐operative variables (operative duration, complications, blood loss, transfusion rate, hospitalization, catheterization), oncological data (Gleason score, pathological stage, positive margins) were also compared. The extent of the systemic response to surgery‐induced tissue trauma was measured in all patients, by assessing the levels of acute‐phase markers C‐reactive protein (CRP), serum amyloid A (SAA), interleukin‐6 (IL‐6) and IL‐10 before, during and after RP. RESULTS The duration of surgery, transfusion rate, hospital stay and duration of catheterization were comparable with those in previous studies. There was an increase in IL‐6, CRP and SAA but no change in IL‐10, and no differences between eLRP and RRP over the entire period assessed. CONCLUSION The invasiveness of eLRP could not be substantiated objectively based on the variables measured in this study. The surgical trauma and associated invasiveness of both methods were equivalent.