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A randomized prospective trial evaluating testosterone, haemoglobin kinetics and quality of life, during and after 12 months of androgen deprivation after prostatectomy: results from the Postoperative Adjuvant Androgen Deprivation trial
Author(s) -
Black Peter C.,
BasenEngquist Karen,
Wang Xuemei,
Swartz Richard J.,
Eddings Teresa,
Matin Surena F.,
Swanson David,
Wood Christopher G.,
Pisters Louis L.,
Babaian Richard J.,
Troncoso Patricia,
Pettaway Curtis A.
Publication year - 2007
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/j.1464-410x.2007.06846.x
Subject(s) - medicine , androgen deprivation therapy , testosterone (patch) , randomized controlled trial , sexual function , quality of life (healthcare) , urology , androgen , prostatectomy , prospective cohort study , prostate cancer , concomitant , adjuvant , surgery , cancer , hormone , nursing
OBJECTIVE To assess testosterone and haemoglobin kinetics in the Postoperative Adjuvant Androgen Deprivation (PAAD) trial, and correlate these with quality of life (QoL) in this prospective randomized study. PATIENTS AND METHODS Forty‐three patients met the criteria for high‐risk cancer after RRP (Gleason score ≥ 8, pT3c or Gleason score 7 concomitant with pT3a/b and positive surgical margins) and were prospectively randomized to either observation or AD for 12 months. Haemoglobin and testosterone levels were determined and QoL surveyed at regular intervals for 24 months. RESULTS Serum testosterone levels were castrate in 19 of 21 treated patients at 3 months and all at 6 months after starting AD. Levels failed to return to normal at 6 months after stopping treatment in six of 16 (38%) patients, and at 12 months in three of 17 (18%). AD caused a delay in the recovery of haemoglobin levels to normal after RRP. There was no statistically significant decline in the Short Form‐36 QoL score with AD. Scores on the University of California‐Los Angeles Sexual Functioning Scale were decreased during AD, but returned to a level not statistically significantly different from controls after stopping treatment. CONCLUSION A year of adjuvant AD after RRP affected serum haemoglobin, testosterone and sexual function reversibly, with return to control levels within the subsequent year in most patients. No significant effect on overall QoL with AD was detected in the study.