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Association of vitamin D receptor (Fok‐I) polymorphism with the clinical presentation of calcium urolithiasis
Author(s) -
Liu ChiaChu,
Huang ChunHsiung,
Wu WenJeng,
Huang ShuPin,
Chou YiiHer,
Li ChingChia,
Chai CheeYin,
Wu MingTsang
Publication year - 2007
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/j.1464-410x.2007.06775.x
Subject(s) - pathophysiology , neurectomy , medicine , endocrinology , penis , annexin , receptor , denervation , chemistry , biology , pathology , apoptosis , surgery , biochemistry , alternative medicine
OBJECTIVE To investigate the effect of the vitamin D receptor (VDR) Fok I polymorphism on the clinical presentation of calcium urolithiasis, as a Fok I polymorphism in the VDR gene was recently reported to be associated with calcium metabolism disorders. PATIENTS, SUBJECTS AND METHODS In all, 235 patients with calcium urolithiasis and 231 age‐ and sex‐matched healthy controls were recruited from Kaohsiung Medical University Hospital between June 2003 and February 2005. Clinical information on the age at first onset, stone episodes, stone severity and presence of family history were collected from patients with stones. Any VDR Fok I polymorphism was detected using polymerase chain reaction‐based restriction analysis. RESULTS The frequency of VDR Fok I genotypes between the patients and the healthy controls was not significantly different. However, among patients, those with the FF genotype had a significantly higher risk of having more stone episodes (adjusted odds ratio 2.15, 95% confidence interval 1.02–4.54, P = 0.044) and were younger at the first onset (3.23, 1.08–9.63, P = 0.036) than those with the ff genotype. CONCLUSION The VDR Fok I polymorphism might be important in the clinical presentation of patients with calcium urolithiasis, especially for the frequency of stone episodes and age at first onset, although it is not associated with the formation of stones.