Premium
The expression of vascular endothelial growth factor is associated with the risk of cancer progression after radical prostatectomy
Author(s) -
Peyromaure Michaël,
Camparo Philippe,
Badoual Cécile,
Descazeaud Aurélien,
DinhXuan AnhTuan
Publication year - 2007
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/j.1464-410x.2007.06734.x
Subject(s) - prostatectomy , vascular endothelial growth factor , medicine , risk factor , vascular endothelial growth factor c , vegf receptors , oncology , prostate cancer , vascular endothelial growth factor a , cancer , cancer research
OBJECTIVE To analyse the prognostic value of vascular endothelial growth factor (VEGF) in men with clinically localized prostate cancer. PATIENTS AND METHODS Paraffin wax‐embedded sections from the radical prostatectomy (RP) specimens of 40 men operated for clinically localized prostate cancer were used to build tissue microarrays. Of these patients, 17 had cancer progression and bone metastases after RP (group 1), and 23 remained free‐of‐tumour recurrence after RP (group 2). VEGF‐A expression was examined in the RP specimens using immunohistochemistry. RESULTS The groups had similar tumour characteristics in terms of prostate‐specific antigen level, Gleason score, and pathological stage. VEGF‐A expression was significantly higher in group 1 than in group 2 ( P = 0.046). In logistic regression analysis, VEGF‐A expression was the most significant predictive factor of cancer progression after RP. CONCLUSION VEGF‐A expression in prostate cancer tissue is associated with the risk of cancer progression after RP. These results suggest that VEGF‐A expression has a prognostic impact in clinically localized prostate cancer.