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Relevance of the prostate‐specific antigen (PSA) nanotest compared to the classical PSA test in the organized mass screening of prostate cancer
Author(s) -
Azzouzi AbdelRahmene,
Larre Stéphane,
Cormier Luc,
Roupret Morgan,
Valeri Antoine,
Mangin Philippe,
Berthon Philippe,
Villette JeanMarie,
Fiet Jean,
Cussenot Olivier
Publication year - 2007
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/j.1464-410x.2006.06701.x
Subject(s) - intraclass correlation , medicine , prostate specific antigen , immunoassay , prostate cancer , urology , prostate , spearman's rank correlation coefficient , gynecology , gold standard (test) , cancer , statistics , mathematics , immunology , antibody , psychometrics , clinical psychology
OBJECTIVE To assess the reliability of a new measurement of prostate‐specific antigen (PSA) using a blotting‐paper assay (nanotest) compared to the standard PSA immunoassay. SUBJECTS AND METHODS The PSA level was measured in 205 men volunteers (median age 70 years, range 41–75) using a nanotest and a standard PSA immunoassay, collected at the same time; 30 µL of capillary blood placed on to a blotting paper were collected for the nanotest and sent by mail to the same laboratory for the two assays. The results were compared statistically using the Spearman test, the intraclass correlation coefficient and the Bland‐Altman test. RESULTS The nanotest threshold for an abnormal PSA level was 78 pg/mL, which corresponded to a standard PSA value of 3 ng/mL, with a sensitivity of 100%. There was a significant correlation ( r = 0.98, Spearman test; P < 0.001) between the nanotest and the standard PSA assay. The intraclass correlation coefficient was 0.87. The Bland‐Altman test showed a good agreement between the nanotest and the standard PSA assay, but there was an increasing proportional difference with increasing PSA value. CONCLUSION There was a very high correlation between the nanotest and the standard PSA assay, especially for standard PSA levels of <5 ng/mL. Economic and clinical studies are indicated to confirm the utility of the nanotest in organized mass screening of prostate cancer.