Premium
Is using ethanol–glycine irrigating fluid monitoring and ‘good surgical practice’ enough to prevent harmful absorption during transurethral resection of the prostate?
Author(s) -
COLLINS JUSTIN W.,
MACDERMOTT SEAMUS,
BRADBROOK RICHARD A.,
KEELEY FRANK X.,
TIMONEY ANTHONY G.
Publication year - 2006
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/j.1464-410x.2006.06208.x
Subject(s) - glycine , transurethral resection of the prostate , absorption (acoustics) , ethanol , chemistry , therapeutic irrigation , saline , prostate , chromatography , anesthesia , medicine , surgery , biochemistry , amino acid , materials science , cancer , composite material
OBJECTIVE To evaluate the utility of using a tracer of 1% ethanol in 1.5% glycine for the early detection of irrigation fluid absorption during transurethral resection of the prostate (TURP). PATIENTS AND METHODS In all, 126 men undergoing TURP were irrigated with a solution of 1% ethanol and 1.5% glycine; their expired air was tested for ethanol every 20 min, and again at the end of the procedure. Maximum absorption by the breath‐ethanol reading was compared with the serum concentration of absorbed glycine (analysed by anion‐exchange chromatography). RESULTS Complete data on 120 men were assessed; 75% of the men absorbed irrigation fluid, with glycine levels above the normal range. The sodium levels tended to decrease with increasing glycine levels (Spearman’s rank correlation coefficient, − 0.57; 120 men) and five men (4%) developed clinical features of the TUR syndrome. There was a weak correlation between breath‐ethanol levels and serum glycine levels (Spearman’s rank correlation coefficient, 0.54). The experience of the surgeon, the weight of the resected chips, and the operative duration were not significantly predictive of irrigation fluid absorption. CONCLUSIONS A rising breath‐ethanol level indicates irrigation fluid absorption. However, irrigating fluid absorption is unpredictable, supporting the case for alternative, potentially safer irrigants.