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Interfering with cell‐survival signalling as a treatment strategy for prostate cancer
Author(s) -
CORCORAN NIALL M.,
COSTELLO ANTHONY J.,
HOVENS CHRISTOPHER M.
Publication year - 2006
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/j.1464-410x.2006.06198.x
Subject(s) - prostate cancer , medicine , nephrectomy , cancer , transplantation , argument (complex analysis) , prostate , oncology , laparoscopy , bioinformatics , kidney , surgery , biology
Authors from Australia describe how interfering with cell survival is increasingly being chosen as a method of developing a treatment strategy for hormone‐resistant prostate cancer. The authors show how several developmental drug candidates have preclinical and clinical activity against cell survival proteins, and that these might be worth considering as possible clinical entities in this condition. The commonly stated argument that laparoscopy has advanced the cause of donor nephrectomy in renal transplantation is examined by authors from the UK. They present a review of the published reports and show that the evidence base is poor for drawing a conclusion as to whether laparoscopic or open nephrectomy is best.