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Botulinum toxin for treatment of non‐neurogenic bladders in children – a case series
Author(s) -
RAO R.,
BARKER A.
Publication year - 2006
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/j.1464-410x.2006.06085_81.x
Subject(s) - medicine , overactive bladder , nocturia , urology , refractory (planetary science) , botulinum toxin , urinary system , detrusor muscle , urinary retention , urinary incontinence , urinary bladder , anesthesia , surgery , physics , alternative medicine , pathology , astrobiology
Objective: Several studies have shown that intradetrusor injections of botulinum neurotoxin type A may effectively treat intractable spinal neurogenic detrusor overactivity, but fewer reports exist on the use of Botulinum toxin in children with non‐neurogenic detrusor overactivity. The purpose of this study was to investigate the effect of Botulinum injections in the treatment of non‐neurogenic bladders in children. Methods: Six children with overactive bladder symptoms were treated. Their disorder had been refractory to anticholinergics, bladder training and neuromodulation. Urodynamic studies confirmed idiopathic detrusor overactivity. Total of 300 U Botox A was injected into the dome of the bladder as 30 × 10 U injections. For follow up a bladder diary and validated urgency and incontinence charts were completed by patients at 1, 3 6 months. Results: Bladder diaries indicated clear reduction in daytime frequency and nocturia and reduction in pad use. Maximal voiding volume increased significantly. All 6 patients were dry after 6 months. No side effects occurred specifically urinary tract infections or retention.Time Dry Partial Response Nil Response2 weeks 1 4 1 4 weeks 3 3 0 12 weeks 6Conclusions: Botox A injection has positive effects in treating non‐neurogenic bladder overactivity in children.