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Location of a positive biopsy as a predictor of surgical margin status and extraprostatic disease in radical prostatectomy
Author(s) -
TOUMA NAJI J.,
CHIN JOSEPH L.,
BELLA TONY,
SENER ALP,
IZAWA JONATHAN I.
Publication year - 2006
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/j.1464-410x.2006.05968.x
Subject(s) - biopsy , medicine , prostatectomy , prostate cancer , urology , predictive value , pathological , basal (medicine) , surgical margin , radical retropubic prostatectomy , radiology , cancer , insulin
OBJECTIVE To investigate whether the location of preoperative biopsy positive cores can identify patients at higher risk of a positive surgical margin (SM) and extraprostatic extension (EPE) at radical retropubic prostatectomy (RRP). PATIENTS AND METHODS We retrospectively reviewed the clinical and pathological data of 371 patients who had a RRP for biopsy confirmed prostate cancer between January 2000 and October 2003. RESULTS A positive biopsy at the apex was not predictive of a positive apical SM or EPE. However, a positive biopsy at the base was predictive of a positive basal SM and EPE. A positive SM, in turn, correlated with EPE on final pathology. Positive basal SM correlated with EPE in 75% of cases whereas positive apical SM showed EPE in only 33% ( P < 0.02). CONCLUSION A positive biopsy core at the base appears to correlate with a positive basal SM and EPE. A positive basal SM correlates with EPE at a higher rate than apical SMs.