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A single‐nucleotide polymorphism in the XPG gene, and tumour stage, grade, and clinical course in patients with nonmuscle‐invasive neoplasms of the urinary bladder
Author(s) -
SAKANO SHIGERU,
KUMAR RAJIV,
LARSSON PER,
ONELÖV ERIK,
ADOLFSSON JAN,
STEINECK GUNNAR,
HEMMINKI KARI
Publication year - 2006
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/j.1464-410x.2005.05994.x
Subject(s) - genotype , single nucleotide polymorphism , odds ratio , snp , biology , confidence interval , gastroenterology , oncology , medicine , restriction fragment length polymorphism , gene , urinary system , stage (stratigraphy) , urinary bladder , pathology , genetics , paleontology
OBJECTIVE To evaluate whether the single nucleotide polymorphism (SNP), Asp1104His (G3507C), in the XPG gene affects malignant phenotypes of nonmuscle‐invasive urinary bladder neoplasms (NIBN), by investigating associations between the SNP and clinicopathological variables in patients with NIBN. PATIENTS AND METHODS The 233 patients constituted newly diagnosed cases of primary NIBN in the Stockholm area. The Asp1104His polymorphism in the XPG gene was genotyped using a polymerase chain reaction‐restriction fragment length polymorphism technique. RESULTS The GC + CC genotypes were more frequent in stage pT1 tumours at initial diagnosis than pTa (odds ratio 1.9, 95% confidence interval 1.0–3.5, P = 0.048). The difference was larger in the young group (4.6, 1.9–11.8, P = 0.001). In the young group, the GC + CC genotypes were significantly more frequent in high‐grade than in low‐grade tumours (3.1, 1.5–6.8, P = 0.004) whereas in the older group the genotypes were less frequent in high‐grade tumours (0.3, 0.1–0.7, P = 0.007). The XPG genotypes were not associated with tumour recurrence, stage progression or survival. CONCLUSION These results suggest that the SNP in the XPG gene might be related to tumour invasiveness in NIBN.