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Preoperative administration of chlormadinone acetate reduces blood loss associated with transurethral resection of the prostate: a prospective randomized study
Author(s) -
Ukimura Osamu,
Kawauchi Akihiro,
Kanazawa Motohiro,
Miyashita Hiroaki,
Yoneda Kimihiko,
Kojima Munekado,
Nakanouchi Tsuneyuki,
Miki Tsuneharu
Publication year - 2005
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/j.1464-410x.2005.05575.x
Subject(s) - medicine , urology , prostate , chlormadinone acetate , blood loss , transurethral resection of the prostate , randomized controlled trial , hyperplasia , prospective cohort study , surgery , population , cancer , research methodology , environmental health
OBJECTIVES To assess the effects of giving chlormadinone acetate (CMA) before surgery on blood loss associated with transurethral resection of the prostate (TURP), in a prospective randomized controlled study. PATIENTS AND METHODS Candidates for TURP among patients with benign prostatic hyperplasia were randomized to either treatment with CMA (CMA+) or not (CMA−). In principle, CMA was started at least 28 days before TURP and continued until just before surgery. RESULTS In all, 33 patients in the CMA+ (median duration of treatment 34.5 days) and 38 in the CMA− group were evaluable. The mean blood loss during TURP was less in the CMA+ (237.3 mL) than in the CMA− group (263.1 mL), but the difference was not significant. There was significantly less blood loss per gram of resected prostate tissue in the CMA+ (9.6 mL/g) than in the CMA− group (13.3 mL/g) ( P < 0.05). Haematuria on the day of and the day after TURP was also significantly less severe in the CMA+ than in the CMA− group ( P < 0.001 and P < 0.05, respectively). The mean microvessel density of resected prostate tissue was significantly less after CMA treatment ( P < 0.001). CONCLUSIONS CMA given for 1 month before TURP could reduce blood loss to some extent during and after TURP, and this may be related to a decrease in microvessel density.