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Gleason grading of prostate cancer in needle biopsies or radical prostatectomy specimens: contemporary approach, current clinical significance and sources of pathology discrepancies
Author(s) -
Montironi Rodolfo,
Mazzuccheli Roberta,
Scarpelli Marina,
LopezBeltran Antonio,
Fellegara Giovanni,
Algaba Ferran
Publication year - 2005
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/j.1464-410x.2005.05540.x
Subject(s) - prostatectomy , medicine , prostate cancer , grading (engineering) , pathological , urology , biopsy , prostate , prostate specific antigen , surgical margin , pathology , oncology , cancer , civil engineering , engineering
The Gleason grading system is a powerful tool to prognosticate and aid in the treatment of men with prostate cancer. The needle biopsy Gleason score correlates with virtually all other pathological variables, including tumour volume and margin status in radical prostatectomy specimens, serum prostate‐specific antigen levels and many molecular markers. The Gleason score assigned to the tumour at radical prostatectomy is the most powerful predictor of progression after radical prostatectomy. However, there are significant deficiencies in the practice of this grading system. Not only are there problems among practising pathologists but also a relative lack of interobserver reproducibility among experts.