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Prognostic significance of insulin‐like growth factor (IGF) binding protein‐2 to IGF‐binding protein‐3 ratio in patients undergoing radical cystectomy for invasive transitional cell carcinoma of the bladder
Author(s) -
Miyake Hideaki,
Hara Isao,
Yamanaka Kazuki,
Muramaki Mototsugu,
Eto Hiroshi
Publication year - 2005
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/j.1464-410x.2005.05453.x
Subject(s) - cystectomy , urology , growth factor , insulin like growth factor , cancer research , insulin like growth factor binding protein , medicine , transitional cell carcinoma , oncology , bladder cancer , endocrinology , cancer , receptor
OBJECTIVES To analyse the prognostic significance of insulin‐like growth factor binding protein‐2 (IGFBP‐2) and IGFBP‐3 in patients having a radical cystectomy for invasive bladder cancer. PATIENTS AND METHODS Tissue samples of invasive bladder cancer were obtained from 97 patients who had radical cystectomy. The expression of IGFBP‐2 and IGFBP‐3 mRNAs in these samples was measured by real‐time reverse transcription‐polymerase chain reaction (RT‐PCR), and the findings analysed in relation to clinicopathological factors. RESULTS During the observation period, 31 patients (group A) developed disease recurrence, while the remaining 66 (group B) had no evidence of recurrence. The expression level of IGFBP‐2 mRNA was significantly higher in group A than in B, while IGFBP‐3 mRNA expression was significantly lower in group A than in B, and there was a significant difference in the relative expression ratio of IGFBP‐2 to IGFBP‐3 (BP‐2/BP‐3 ratio) between the groups. Recurrence‐free survival in patients with an elevated BP‐2/BP‐3 ratio was significantly lower than in those with a normal ratio. Multivariate analysis indicated that an elevated BP‐2/BP‐3 ratio, but not IGFBP‐2 and IGFBP‐3 mRNA levels, was an independent predictor of disease recurrence. CONCLUSIONS These findings suggest that the BP‐2/BP‐3 ratio measured by real‐time RT‐PCR could be useful for predicting disease recurrence in patients who have had a radical cystectomy for invasive bladder cancer.