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Use of combined intracorporal injection and a phosphodiesterase‐5 inhibitor therapy for men with a suboptimal response to sildenafil and/or vardenafil monotherapy after radical retropubic prostatectomy
Author(s) -
Mydlo Jack H.,
Viterbo Rosalia,
Crispen Paul
Publication year - 2005
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/j.1464-410x.2005.05413.x
Subject(s) - vardenafil , medicine , erectile dysfunction , sildenafil , radical retropubic prostatectomy , prostatectomy , urology , shim (computing) , pharmacotherapy , cgmp specific phosphodiesterase type 5 , prostate cancer , surgery , combination therapy , tadalafil , cancer
Associate Editor Michael G. Wyllie Editorial Board Ian Eardley, UK Jean Fourcroy, USA Sidney Glina, Brazil Julia Heiman, USA Chris McMahon, Australia Bob Millar, UK Alvaro Morales, Canada Michael Perelman, USA Marcel Waldinger, Netherlands OBJECTIVE To report experience with combined therapy using intracorporal injection (ICI) of alprostadil and oral phosphodiesterase 5 (PDE‐5) inhibitors for the minimally invasive treatment of erectile dysfunction (ED) after radical prostatectomy (RP), as PDE‐5 inhibitors are effective but a few patients may have a suboptimal response. PATIENTS AND METHODS In a retrospective study, 34 men (aged 46–66 years) had a nerve‐sparing retropubic RP and subsequent ED. Patients were titrated on sildenafil citrate or vardenafil to maximum doses. All had a suboptimal response after a maximum of eight doses of oral therapy and were then treated with ICI therapy using 15 or 20 µg alprostadil. Erectile function was assessed with the Sexual Health Inventory for Men (SHIM). RESULTS Of the 32 patients who continued combined therapy, 22 (68%) had an improvement in erectile function after ICI therapy, as assessed by the SHIM score. On follow‐up, 36% of these patients used ICI therapy only intermittently, instead of regularly, as they felt that this was adequate enough for good results. CONCLUSIONS PDE‐5 oral pharmacotherapy is the most commonly used effective therapy for ED but may not be as effective in patients who have radical surgery; the addition of testosterone patches may have side‐effects or be considered a risk in patients with a history of prostate cancer. The use of ICI therapy as an adjunct or maintenance therapy to their oral medication may be another alternative in these patients.