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Interleukin‐4 gene intron‐3 polymorphism is associated with transitional cell carcinoma of the urinary bladder
Author(s) -
Tsai FuuJen,
Chang ChaoHsiang,
Chen ChangChung,
Hsia TeChun,
Chen HueyYi,
Chen WenChi
Publication year - 2005
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/j.1464-410x.2005.05315.x
Subject(s) - genotype , bladder cancer , exon , allele , transitional cell carcinoma , intron , biology , urinary bladder , gene , gene polymorphism , microbiology and biotechnology , cancer research , genetics , medicine , cancer
OBJECTIVE To evaluate whether polymorphism of the interleukin‐4 gene exon 3, and of the interleukin‐1β gene exon 5 and promoter region, are associated with transitional cell carcinoma (TCC) of the urinary bladder, as cytokines are hypothesized to be important in cancer formation. PATIENTS, SUBJECTS AND METHODS The study included 138 patients with TCC of urinary bladder and 105 healthy controls living in the same area. Each genetic polymorphism was typed using polymerase chain reaction‐based restriction analysis. Genotype distribution and allelic frequencies between patients and controls were compared. RESULTS There were significant differences in genotype and allelic distribution of intron 3 RP1/RP2 polymorphism ( P < 0.001), but no significant difference in genotype distribution or allelic frequencies of the interleukin‐1β gene polymorphism between patients with bladder cancer and controls. CONCLUSION The interleukin‐4 gene intron 3 polymorphism is associated with bladder cancer and is a potential genetic marker in screening for the possible causes of bladder cancer.