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Treatment of stress urinary incontinence using a copolymer system: impact on quality of life
Author(s) -
Van Kerrebroeck Philip,
Ter Meulen Flip,
Larsson Gregor,
Farrelly Elisabeth,
Edwall Lena,
FianuJonasson Aino
Publication year - 2004
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/j.1464-410x.2004.05101.x
Subject(s) - medicine , urinary incontinence , quality of life (healthcare) , urology , stress incontinence , prospective cohort study , urinary system , physical therapy , surgery , nursing
OBJECTIVE To investigate the effect on quality of life (QoL) of a novel system for treatment of stress urinary incontinence (SUI). PATIENTS AND METHODS In an open, prospective, multicentre study, 42 women not previously treated by invasive therapy and with urodynamically verified SUI received 4 × 1.0 mL or 4 × 0.7 mL of non‐animal stabilized hyaluronic acid/dextranomer copolymer injected transurethrally into the urethra via the Implacer TM device (Zuidex TM system, Q‐Med AB, Uppsala, Sweden). QoL was assessed using the King's Health Questionnaire. The patients’ perception of treatment benefit and the number of incontinence episodes/24 h were also investigated. RESULTS There were significant improvements over baseline in seven of 10 domains of the King's Health Questionnaire at 3 months, and these improvements were sustained at 1 year. For the change from baseline to 1 year, eight of 10 domains showed a significant positive correlation with the number of incontinence episodes/24 h. In terms of treatment benefit, most of the women perceived an improvement at 1, 3, 6 and 12 months. Of the 18 women requiring re‐treatment, most perceived an improvement at 3, 6 and 12 months. CONCLUSION Treatment with the Zuidex system produced significant improvements over a year in both subjective QoL and objective incontinence measures, with a significant positive correlation between them.