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Reconstruction of the sympathetic pathway projecting to the prostate, by nerve grafting in the dog
Author(s) -
Hyochi Nobuhiko,
Kihara Kazunori,
Arai Gaku,
Kobayashi Tsuyoshi,
Sato Kenji
Publication year - 2004
Publication title -
bju international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 1464-4096
DOI - 10.1111/j.1464-410x.2004.04915.x
Subject(s) - medicine , prostate , hypogastric nerve , lumbar plexus , autonomic nerve , contraction (grammar) , splanchnic nerves , sympathetic nerve , urology , anatomy , lumbar , stimulation , cancer
OBJECTIVES To examine the possibility of nerve grafting to repair the sympathetic pathway projecting to the prostate, as contraction of the prostate is known to be controlled by the sympathetic pathway via the hypogastric nerve (HGN), and injuries to the pathway cause significant disturbances in prostatic secretion. MATERIALS AND METHODS In six dogs both of the HGNs were partly removed and immediately repaired with an autologous nerve graft. The left HGN was repaired with a colonic (autonomic) nerve graft and the right with a genitofemoral (somatic) nerve graft. Twenty months after surgery the reconstruction of the sympathetic pathway was assessed by measuring contraction of the prostate after stimulating the lumbar splanchnic nerves (LSNs). RESULTS Nine of the 17 right LSNs stimulated elicited prostatic contractions. After transecting the left HGN five of these nine responses were restored. Seven of the 11 left LSNs stimulated elicited prostatic contractions; after transection of the left HGN four of these seven responses were preserved. CONCLUSION The sympathetic pathways via the HGN to the canine prostate can be reconstructed by nerve grafting, regardless of the use of autonomic or somatic nerve grafts, and the cross‐innervation mechanism from the LSN to the prostate can also be repaired.