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Fetal penile and urethral development subsequent to vascular insult in the last trimester of gestation: an experimental study in goat fetuses*
Author(s) -
KIZILCAN F.,
KARNAK I.,
TANYEL F.C.,
CAKAR N.,
BUYUKPAMUKCU N.,
HICSONMEZ A.
Publication year - 1995
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1995.tb07756.x
Subject(s) - fetus , gestation , medicine , insult , pregnancy , biology , philosophy , linguistics , genetics
Objective To investigate a possible mechanism (the vascular theory) in the development of congenital anomalies of the penis and urethra in the fetus of the goat. Materials and methods Fifteen male Angora goat fetuses underwent an operation at 110–114 days of gestation whereby branches of the internal pudendal artery within the superficial compartment of the perineum were ligated. Five male fetuses served as controls in which the perineum was explored with no ligation. Results Five treated and three control live offspring were delivered spontaneously. Although no genitourinary anomalies were observed on gross examination, histopathological examination of the penises of treated animals revealed smaller penises with increased fibrosis. Conclusion A defective vascular supply can partly explain the morphogenesis of some aspects of the congenital anomalies of the penis and urethra.