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Pain relief and quality‐of‐life assessment following intravenous and oral clodronate in hormone‐escaped metastatic prostate cancer
Author(s) -
CRESSWELL S.M.,
ENGLISH P.J.,
HALL R.R.,
ROBERT J.T.,
MARSH M.M.
Publication year - 1995
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1995.tb07715.x
Subject(s) - medicine , quality of life (healthcare) , prostate cancer , performance status , prostate , cancer , bone pain , oncology , nursing
Objective To establish the efficacy of intravenous clodronate followed by maintenance oral clodronate in patients with painful bone metastases resulting from hormone‐resistant prostate cancer. Patients and methods A multicentre open study of 27 patients assessed the efficacy of clodronate treatment by estimating the reduction in World Health Organization (WHO) Pain Score, the increase in WHO Performance Status and by a novel quality‐of‐life/ activity score. Results Ten of 27 patients achieved significant pain relief after receiving 300 mg/day of intravenous clodronate for 10 days. This was matched by an improvement in the activity score and WHO Performance Status. Three of 27 patients continued to have relief from pain after 3 months of oral clodronate therapy. Conclusion Intravenous clodronate therapy was effective in relieving the pain resulting from prostate cancer bone metastases in 10 of 27 patients but the benefit was shortlived. The use of a personal quality‐of‐life/ activity questionnaire which assesses aspects of everyday life that are important to the patient may be more appropriate for patients with very advanced prostate cancer than are other quality‐of‐life questionnaires in current use.