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Serum intercellular adhesion molecule (ICAM‐1), a marker of renal scarring in infants with vesico‐ureteric reflux
Author(s) -
MIYAKITA H.,
PURI P.,
SURANA R.,
KOBAYASHI H.,
REEN D.J.
Publication year - 1995
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1995.tb07685.x
Subject(s) - reflux , intercellular adhesion molecule 1 , icam 1 , adhesion , medicine , urology , cell adhesion molecule , pathology , chemistry , immunology , disease , organic chemistry
Objective To determine if serum intercellular adhesion molecule (ICAM‐1) levels correlate with renal scarring in children with vesico‐ureteric reflux (VUR). Patients and methods Serum ICAM‐1 levels were measured in 81 children (29 boys and 52 girls, age range 2 months‐13 years) with VUR using an enzyme‐linked immunosorbent assay (ELISA) and compared with levels in a control group of 24 children (16 boys and eight girls, age range 2 days‐13 years) with no urological abnormalities. Results The mean serum ICAM‐1 level in the control group was 202±79 ng/mL (mean±l SD) compared with 347±96 ng/mL in children with VUR (P<0.001). Fifteen of 26 children under 2 years of age demonstrated renal scarring while 18 of 44 children older than 2 years exhibited renal scarring. The mean serum ICAM‐1 level in patients who were <2 years of age and had renal scarring was 408 +ng/mL, significantly higher than in those who had no renal scarring (296± 68 ng/mL, P > 0.01). In contrast, there was no difference in serum ICAM‐1 levels in patients > 2 years of age with or with no renal scarring (353 + 87 and 325 + 91 ng/mL, respectively). Conclusion Serum ICAM‐1 levels are significantly higher in children with VUR and may represent a valuable marker of tubular damage in younger children with VUR.