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Prognostic evaluation of morphonuclear parameters in superficial and invasive bladder cancer
Author(s) -
Colombel M.,
Launoit Y.,
Bellot J.,
Kiss R.,
Abbou C.,
Chopin D.
Publication year - 1995
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1995.tb07350.x
Subject(s) - medicine , optical density , bladder cancer , urology , nuclear medicine , cancer , oncology , ophthalmology
Objective To assess the prognostic value of morphonuclear parameters determined by means of computerized image analysis in untreated bladder tumours. Patients and methods Fifty patients had untreated bladder cancer; in 28 patients the tumours were superficial (7pTlGl; 14pTlG2; 7pTlG3) and in 22 they were invasive (6T2G2, 9T2G3, 2T3G2, 5T3G3). Feulgen‐stained imprints were processed for morphonuclear analysis on a SAMBA 200 computerized image analysis system (T1TN, France), which measures optical density (integrated optical density, IOD; surface area, SURF; mean optical density, MOD), texture (long run length, LRL; short run length, SRL; run length distribution, RID; run length percentage, RLP; grey level distribution, GLD) and contrast (contrast, C; energy, E). Results Morphonuclear parameters IOD, SURF, LRL, SRL and C were found to correlate with the risk of recurrence and progression of superficial bladder tumours (Results for ANOVA respectively IOD P<0.001; SURF P = 0.02; LRL P = 0.05; RLD P = 0.04; SRL P = 0.04; C P<0.001). In invasive bladder cancer, parameters IOD and C only correlated with the risk of progression (ANOVA respectively IOD P <0.001; C P <0.001). On the other hand, progression‐free curve analysis using the Kaplan Meier method showed that morphonuclear parameters may be useful in predicting the outcome for superficial tumours (Log/Rank test: SURF P<0.001; RLD <0.001; SRL = 0.003; LRL <0.001; C<0.001; IOD<0.001). In the case of invasive tumours, only two parameters provided prognostic information (Logrank test: C<0.001; IOD<0.001). Conclusion Nuclear morphometry assessed by image analysis is potentially useful in assessing the prognosis of bladder tumours; it provides Objective and quantitative parameters. Further studies will determine whether morphonuclear analysis can be used to monitor the treatment of bladder cancer, particularly superficial tumours.