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Alpha 1 ‐adrenoceptor subtypes in the human prostate
Author(s) -
CHAPPLE C.R.,
BURT R.P.,
ANDERSSON P.O.,
GREENGRASS P.,
WYLLIE M.,
MARSHALL I.
Publication year - 1994
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1994.tb09188.x
Subject(s) - prostate , alpha (finance) , radioligand , adrenergic receptor , endocrinology , hamster , medicine , pharmacology , chemistry , receptor , construct validity , nursing , cancer , patient satisfaction
Objective To determine the subset of α 1 ‐adrenoceptors mediating the functional abstraction of the prostate to noradrenaline. Materials and methods Radioligand experiments were performed with membranes prepared from rat 1 fibroblasts trasfected with rat α 1a , hamster α 1b or bovine α 1c adrenoceptor cDNA. Human prostatic tissue obtained from transurethral resection of the prostate with full informed consent was submitted to functional in vitro muscle strip experiments. Results The binding experiments defined the potential subtype selectivity of various antagonists. Using this information, it was possible to define the functionally important α 1 ‐adrenoceptor subtype in the human prostate. Conclusion This work reports the results of the first functional characterization of the α 1c ‐adrenoceptor subtype. The most functionally important α 1 ‐ceptor type in the human prostate appears to be the α 1c subtype. This finding may aid the development of prostate‐selective adrenoceptor pharmacotherapy.