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Alkali citrate prophylaxis in idiopathic recurrent calcium oxalate urolithiasis — a prospective randomized study
Author(s) -
HOFBAUER J.,
HÖBARTH K.,
SZABO N.,
MARBERGER M.
Publication year - 1994
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1994.tb07597.x
Subject(s) - medicine , calcium oxalate , calcium , surgery
Objective To assess the efficacy of alkali citrate therapy in patients suffering from recurrent idiopathic calcium oxalate stone formation. Patients and methods Fifty patients suffering from active stone formation who had had at least one stone annually over the previous 3 years were recruited and randomly divided into two groups. They were given either general prophylactic instructions, i.e. abundant liquid intake and dietary restrictions (group I, n = 25) ‐ or were additionally treated with alkali citrate (group 11, n=25). Results In group I, the rate of stone formation was reduced from 1.8 to 0.7 stones per patient per year. Similar results were obtained for group 11, the corresponding figures being 2.1 and 0.9. There was a statistically significant higher urinary citrate excretion in group I1 than in group I. No difference was seen between the two groups regarding recurrent stone formation (Student's t‐test). Stone formation decreased in both groups (group I 27% group I1 31%). Subjectively, 56% of group I1 patients, all of whom had previously experienced severe colic, reported spontaneous stone elimination to be painless, whereas in group I all but one patient suffered pain. Conclusion An objective benefit of alkali citrate could not be established.