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Dicentric Y Chromosome in Azoospermic Males
Author(s) -
TAKIHARA H.,
TSUKAHARA M.,
BABA Y.,
NAITO K.,
KAJII T.
Publication year - 1993
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1993.tb16032.x
Subject(s) - azoospermia , dicentric chromosome , centromere , long arm , y chromosome , biology , chromosome , andrology , karyotype , genetics , anatomy , gene , medicine , infertility , pregnancy
Summary— Two azoospermic, infertile men with a pseudodicentric Y chromosome are reported. The small isodicentric Y chromosomes were composed of duplicated short arm and proximal long arm Y, as proven by fluorescence in situ hybridisation using a Y centromere‐specific DNA probe, pDP97, and a short arm probe pY‐80. Both lacked germinal cells in the gonads. It was assumed that the azoospermia was caused by deletion or disruption of the azoospermic factor gene located at distal Yq11. Patient 2 measured 147 cm (—4.1 SD) in height and so it was assumed that he had also lost the “statural determinants” gene.