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Why do Most Primary Bladder Neoplasms First Appear Around the Ureteric Orifices?
Author(s) -
STEWART L. H.,
O'NEILL K. L.,
McKELVEY V. J.,
GILLESPIE E. S.,
JOHNSTON S. R.,
BIGGART J. D.,
McKENNA P. G.
Publication year - 1993
Publication title -
british journal of urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.773
H-Index - 148
eISSN - 1464-410X
pISSN - 0007-1331
DOI - 10.1111/j.1464-410x.1993.tb15876.x
Subject(s) - ureter , urinary bladder , isozyme , biology , pathology , medicine , enzyme , urology , biochemistry
Summary The majority of primary bladder neoplasms are known to arise within the mucosa around the ureteric orifices and bladder base. This may be due to the mucosa in this area being more susceptible to carcinogens than other areas of the bladder. Deficiency in the nucleotide salvage pathway enzyme thymidine kinase (TK), and especially its TK 1 isozyme, has been shown to predispose cell lines to increased mutagenesis. Total TK and TK 1 activities were measured in mucosal samples taken adjacent to the ureteric orifices and dome in 32 normal bladders and both total TK and TK 1 were shown to be significantly decreased in the mucosa adjacent to the ureteric orifices. This may explain why primary bladder neoplasms occur more commonly in this site.